Identification of Haematopoietic Stem and Progenitor Cell Subpopulations

Grant number: 1124812 | Funding period: 2018 - 2020

Completed

Abstract

We want to dissect the machinery underlying how each and every individual stem and progenitor cell generates the different blood cell types. We have at our disposal the latest molecular and computational technologies to do this. Knowledge gained from this project could be used for tissue engineering to make blood cells on demand for patients with immune deficiency, or alternatively to treat leukaemia patients where blood cells are overproduced.

Related publications (6)

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Mastering the use of cellular barcoding to explore cancer heterogeneity

A Serrano, J Berthelet, SH Naik, D Merino

2022-11-01

Tumours are often composed of a multitude of malignant clones that are genomically unique, and only a few of them may have the abi..

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Erratum: The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis (Development (Cambridge) (2021) 148 (dev199581) DOI: 10.1242/dev.199581)

ZL Grant, PF Hickey, W Abeysekera, L Whitehead, SM Lewis, RCA Symons, TM Baldwin, D Amann-Zalcenstein, AL Garnham, SH Naik, GK Smyth, T Thomas, AK Voss, L Coultas

2021-12-01

Shalin H. Naik was inadvertently omitted from the author list. The complete list of authors, their affiliations, contributions and..

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Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time

GE Lidgerwood, A Senabouth, CJA Smith-Anttila, V Gnanasambandapillai, DC Kaczorowski, D Amann-Zalcenstein, EL Fletcher, SH Naik, AW Hewitt, JE Powell, A Pébay

2021-04-01

Human pluripotent stem cell (hPSC)-derived progenies are immature versions of cells, presenting a potential limitation to the accu..

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A new lymphoid-primed progenitor marked by Dach1 downregulation identified with single cell multi-omics

D Amann-Zalcenstein, L Tian, J Schreuder, S Tomei, DS Lin, KA Fairfax, JE Bolden, MD McKenzie, A Jarratt, A Hilton, JT Jackson, L Di Rago, MP McCormack, CA de Graaf, O Stonehouse, S Taoudi, WS Alexander, SL Nutt, ME Ritchie, AP Ng

2020-12-01

A classical view of blood cell development is that multipotent hematopoietic stem and progenitor cells (HSPCs) become lineage-rest..

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Dendritic cell development at a clonal level within a revised ‘continuous’ model of haematopoiesis

SH Naik

2020-08-01

Understanding development of the dendritic cell (DC) subtypes continues to evolve. The origin and relationship of conventional DC ..

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Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

D Merino, TS Weber, A Serrano, F Vaillant, K Liu, B Pal, L Di Stefano, J Schreuder, D Lin, Y Chen, ML Asselin-Labat, TN Schumacher, D Cameron, GK Smyth, AT Papenfuss, GJ Lindeman, JE Visvader, SH Naik

2019-12-01

Primary triple negative breast cancers (TNBC) are prone to dissemination but sub-clonal relationships between tumors and resulting..

University of Melbourne Researchers